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Index > Protein center > Ctnnd1(Gene name) > Mouse
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  • Ctnnd1 (Gene name),
  • Catenin delta-1 (Protein name ),  CTND1_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Ctnnd1(Catns;Kiaa0384);
    Protein name:
    Catenin delta-1;
    Alternative:
    p120 catenin(p120(ctn));Cadherin-associated Src substrate(CAS);p120(cas);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Belongs to a multiprotein cell-cell adhesion complex that also contains E-cadherin, alpha-catenin, beta-catenin, and gamma-catenin. Binds to the C-terminal fragment of PSEN1 and mutually competes for E-cadherin (By similarity). Interacts with ZBTB33. Interacts with GLIS2 and FER. Interacts with NANOS1 (via N-terminal region).
    Function:
    May associate with and regulate the cell adhesion properties of both C- and E-cadherins. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (By similarity). Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway. Promotes GLIS2 C-terminal cleavage.
    Subcellular Location:
    Cytoplasm Nucleus Cell membrane Interaction with GLIS2 promotes nuclear translocation. NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm.
    Protein Attributes:
    Sequence length:
    938
    Sequence:
    50:
    MDDSEVESTA | SILASVKEQE | AQFEKLTRAL | EEERRHVSAQ | LERVRVSPQD | 
    100:
    ANSLMANGTL | TRRHQNGRFV | GDADLERQKF | SDLKLNGPQD | HNHLLYSTIP | 
    150:
    RMQEPGQIVE | TYTEEDPEGA | MSVVSVETTD | DGTTRRTETT | VKKVVKTMTT | 
    200:
    RTVQPVPMGP | DGLPVDASAV | SNNYIQTLGR | DFRKNGNGGP | GPYVGQAGTA | 
    250:
    TLPRNFHYPP | DGYGRHYEDG | YPGGSDNYGS | LSRVTRIEER | YRPSMEGYRA | 
    300:
    PSRQDVYGPQ | PQVRVGGSSV | DLHRFHPEPY | GLEDDQRSMG | YDDLDYGMMS | 
    350:
    DYGTARRTGT | PSDPRRRLRS | YEDMIGEEVP | PDQYYWAPLA | QHERGSLASL | 
    400:
    DSLRKGMPPP | SNWRQPELPE | VIAMLGFRLD | AVKSNAAAYL | QHLCYRNDKV | 
    450:
    KTDVRKLKGI | PILVGLLDHP | KKEVHLGACG | ALKNISFGRD | QDNKIAIKNC | 
    500:
    DGVPALVRLL | RKARDMDLTE | VITGTLWNLS | SHDSIKMEIV | DHALHALTDE | 
    550:
    VIIPHSGWER | EPNEDCKPRH | IEWESVLTNT | AGCLRNVSSE | RSEARRKLRE | 
    600:
    CDGLVDALIF | IVQAEIGQKD | SDSKLVENCV | CLLRNLSYQV | HREIPQAERY | 
    650:
    QEALPTVANS | TGPHAASCFG | AKKGKDEWFS | RGKKPTEDPA | NDTVDFPKRT | 
    700:
    SPARGYELLF | QPEVVRIYIS | LLKESKTPAI | LEASAGAIQN | LCAGRWTYGR | 
    750:
    YIRSALRQEK | ALSAIAELLT | SEHERVVKAA | SGALRNLAVD | ARNKELIGKH | 
    800:
    AIPNLVKNLP | GGQQNSSWNF | SEDTVVSILN | TINEVIAENL | EAAKKLRETQ | 
    850:
    GIEKLVLINK | SGNRSEKEVR | AAALVLQTIW | GYKELRKPLE | KEGWKKSDFQ | 
    900:
    VNLNNASRSQ | SSHSYDDSTL | PLIDRNQKSD | KKPDREEIPM | SNMGSNTKSL | 
    938:
    DNNYSTLNER | GDHNRTLDRS | GDLGDMEPLK | GAPLMQKI
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    Pfam:
    SMR:
    UniGene:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Catenin delta-1
    Cat.:
    E15041m
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    MSDS:
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    96T
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    ELISA Kit for Mouse Catenin delta-1
    Cat.:
    E15041h
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    MSDS:
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    Packing:
    96T
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    CLIA Kit for Mouse Catenin delta-1
    Cat.:
    U15041m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse Catenin delta-1
    Cat.:
    U15041h
    Price:
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Mouse Catenin delta-1
    Cat.:
    P15041Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Catenin delta-1
    Cat.:
    P15041Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Catenin delta-1
    Monoclonal Antibody for Mouse Catenin delta-1
    Protein for Mouse Catenin delta-1
    Protein for Mouse Catenin delta-1

    R&D Technical Data
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "p120, a novel substrate of protein tyrosine kinase receptors and of p60v-src, is related to cadherin-binding factors beta-catenin, plakoglobin and armadillo."
      Reynolds A.B. , Herbert L. , Cleveland J.L. , Berg S.T. , Gaut J.R.
      Oncogene7:2439-2445(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
      strain: Swiss.
    2. 2.
      Reynolds A.B.
      Submitted (1992-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
    3. 3.
      "Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N. , Kikuno R. , Ohara R. , Inamoto S. , Hara Y. , Nagase T. , Ohara O. , Koga H.
      DNA Res.9:179-188(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
      tissue: Brain.
    4. 4.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3)
      strain: C57BL/6J.
      tissue: Testis.
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      strain: C57BL/6.
      tissue: Brain.
    6. 6.
      "The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor."
      Daniel J.M. , Reynolds A.B.
      Mol. Cell. Biol.19:3614-3623(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ZBTB33
    7. 7.
      "The p120(ctn)-binding partner Kaiso is a bi-modal DNA-binding protein that recognizes both a sequence-specific consensus and methylated CpG dinucleotides."
      Daniel J.M. , Spring C.M. , Crawford H.C. , Reynolds A.B. , Baig A.
      Nucleic Acids Res.30:2911-2919(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ZBTB33
    8. 8.
      "NLS-dependent nuclear localization of p120ctn is necessary to relieve Kaiso-mediated transcriptional repression."
      Kelly K.F. , Spring C.M. , Otchere A.A. , Daniel J.M.
      J. Cell Sci.117:2675-2686(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;NUCLEAR LOCALIZATION SIGNAL;SUBCELLULAR LOCATION;MUTAGENESIS OF 622-LYS-LYS-623
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    10. 10.
      "The catenin p120ctn inhibits Kaiso-mediated transcriptional repression of the beta-catenin/TCF target gene matrilysin."
      Spring C.M. , Kelly K.F. , O'Kelly I. , Graham M. , Crawford H.C. , Daniel J.M.
      Exp. Cell Res.305:253-265(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    11. 11.
      "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
      Rush J. , Moritz A. , Lee K.A. , Guo A. , Goss V.L. , Spek E.J. , Zhang H. , Zha X.-M. , Polakiewicz R.D. , Comb M.J.
      Nat. Biotechnol.23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-217; TYR-221 AND TYR-280;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    12. 12.
      "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
      Cao L. , Yu K. , Banh C. , Nguyen V. , Ritz A. , Raphael B.J. , Kawakami Y. , Kawakami T. , Salomon A.R.
      J. Immunol.179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-904;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Mast cell.
    13. 13.
      "The transcriptional repressor Glis2 is a novel binding partner for p120 catenin."
      Hosking C.R. , Ulloa F. , Hogan C. , Ferber E.C. , Figueroa A. , Gevaert K. , Birchmeier W. , Briscoe J. , Fujita Y.
      Mol. Biol. Cell18:1918-1927(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GLIS2;FUNCTION;SUBCELLULAR LOCATION
    14. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-230; SER-252; SER-288; SER-349; SER-847; SER-857; TYR-865 AND SER-899;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Liver.
    15. 15.
      "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
      Zhou H. , Ye M. , Dong J. , Han G. , Jiang X. , Wu R. , Zou H.
      J. Proteome Res.7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-349;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Liver.
    16. 16.
      "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M. , English L. , Lemieux S. , Courcelles M. , Desjardins M. , Thibault P.
      Immunity30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    17. 17.
      "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
      Sweet S.M. , Bailey C.M. , Cunningham D.L. , Heath J.K. , Cooper H.J.
      Mol. Cell. Proteomics8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-228; TYR-257; SER-349; SER-352 AND TYR-904;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic fibroblast.
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